HOTAIR lncRNA SNPs rs920778 and rs1899663 are associated with smoking, male gender, and squamous cell carcinoma in a Chinese lung cancer population

The abnormal expression of the long noncoding RNA (lncRNA) HOX transcript intergenic antisense RNA (HOTAIR) plays an important role in the development of various cancers; however, single nucleotide polymorphisms (SNPs) in HOTAIR and their association with primary lung cancer susceptibility have not...

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Bibliographic Details
Published in:Acta pharmacologica Sinica 2018-11, Vol.39 (11), p.1797-1803
Main Authors: Wang, Cong, Li, Ying, Li, Yong-wen, Zhang, Hong-bing, Gong, Hao, Yuan, Yin, Li, Wei-ting, Liu, Hong-yu, Chen, Jun
Format: Article
Language:English
Subjects:
Adenocarcinoma of Lung - genetics
Adult
Aged
Aged, 80 and over
Antisense RNA
Asian Continental Ancestry Group
Biomedical and Life Sciences
Biomedicine
Carcinoma, Squamous Cell - genetics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Health risk assessment
Health risks
Humans
Immunology
Internal Medicine
Linkage analysis
Linkage disequilibrium
Lung cancer
Lung carcinoma
Lung Neoplasms - genetics
Male
Medical Microbiology
Middle Aged
Pharmacology/Toxicology
Polymorphism, Single Nucleotide
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Single-nucleotide polymorphism
Smoking
Smoking - genetics
Squamous cell carcinoma
Transcription
Vaccine
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Summary:The abnormal expression of the long noncoding RNA (lncRNA) HOX transcript intergenic antisense RNA (HOTAIR) plays an important role in the development of various cancers; however, single nucleotide polymorphisms (SNPs) in HOTAIR and their association with primary lung cancer susceptibility have not yet been reported. Here, we performed a case-control study including 262 primary lung cancer patients and 451 cancer-free control individuals to investigate the association between four haplotype-tagging SNPs (rs920778, rs12826786, rs4759314, and rs1899663) in the HOTAIR lncRNA and the risk of developing primary lung cancer. We found a significant association between the SNPs rs920778 and rs1899663 in the HOTAIR and primary lung cancer susceptibility ( P   T) sites was significantly associated with gender, smoking history, and pathological type. In addition, linkage disequilibrium and haplotype analysis of HOTAIR gene polymorphisms for susceptibility to lung cancer revealed a high degree of linkage disequilibrium between the rs920778 and rs1899663 loci ( D ’ = 0.86, r2 = 0.52). The population of rs920778, rs1899663, and rs4759314 had a significantly increased risk of lung cancer ( P  
ISSN:1671-4083
1745-7254
DOI:10.1038/s41401-018-0083-x