The Impact of Potassium Channel Gene Polymorphisms on Antiepileptic Drug Responsiveness in Arab Patients with Epilepsy

This study aims to investigate the effects of the three potassium channel genes , , and on increased susceptibility to epilepsy as well as on responsiveness to antiepileptic drugs (AEDs). The pharmacogenetic and case-control cohort ( = 595) consisted of 296 epileptic patients and 299 healthy individ...

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Bibliographic Details
Published in:Journal of personalized medicine 2018-11, Vol.8 (4), p.37
Main Authors: Al-Eitan, Laith N, Al-Dalalah, Islam M, Elshammari, Afrah K, Khreisat, Wael H, Almasri, Ayah Y
Format: Article
Language:English
Subjects:
Antiepileptic agents
Ataxia
Chromosomes
Convulsions & seizures
Drug dosages
Epilepsy
Gene polymorphism
Genes
Genetic factors
KCNA1 protein
Medical records
Mutation
Neurology
Patients
Pediatrics
Potassium
Precision medicine
Seizures
Single-nucleotide polymorphism
Susceptibility
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Summary:This study aims to investigate the effects of the three potassium channel genes , , and on increased susceptibility to epilepsy as well as on responsiveness to antiepileptic drugs (AEDs). The pharmacogenetic and case-control cohort ( = 595) consisted of 296 epileptic patients and 299 healthy individuals. Epileptic patients were recruited from the Pediatric Neurology clinic at the Queen Rania Al Abdullah Hospital (QRAH) in Amman, Jordan. A custom platform array search for genetic association in Jordanian-Arab epileptic patients was undertaken. The MassARRAY system (iPLEX GOLD) was used to genotype seven single nucleotide polymorphisms (SNPs) within three candidate genes ( , , and ). Only one SNP in , rs3887820, showed significant association with increased risk of susceptibility to generalized myoclonic seizure ( -value < 0.001). Notably, the rs112561866 polymorphism of the gene was non-polymorphic, but no significant association was found between the (rs2227910, rs112561866, and rs7974459) and (rs7029012, rs10967705, and rs10967728) polymorphisms and disease susceptibility or drug responsiveness among Jordanian patients. This study suggests that a significant association exists between the SNP rs3887820 and increased susceptibility to generalized myoclonic seizure. However, the present findings indicate that the and SNPs do not influence disease susceptibility and drug responsiveness in epileptic patients. Pharmacogenetic and case-control studies involving a multicenter and multiethnic approach are needed to confirm our results. To improve the efficacy and safety of epilepsy treatment, further studies are required to identify other genetic factors that contribute to susceptibility and treatment outcome.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm8040037