Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa

Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder‐specific cues (e.g., food) and presumed rewards (e.g., mon...

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Bibliographic Details
Published in:Human brain mapping 2019-02, Vol.40 (2), p.652-662
Main Authors: Haynos, Ann F., Hall, Leah M. J., Lavender, Jason M., Peterson, Carol B., Crow, Scott J., Klimes‐Dougan, Bonnie, Cullen, Kathryn R., Lim, Kelvin O., Camchong, Jazmin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anorexia
anorexia nervosa
Anorexia Nervosa - diagnostic imaging
Anorexia Nervosa - physiopathology
Body mass
Brain
Caudate Nucleus - diagnostic imaging
Caudate Nucleus - physiopathology
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiopathology
Circuits
Connectome
Disturbances
eating disorder
Eating disorders
Female
Frontal gyrus
functional connectivity
Functional morphology
habit
Habits
Humans
Magnetic Resonance Imaging
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neural networks
Nucleus accumbens
Nucleus Accumbens - diagnostic imaging
Nucleus Accumbens - physiopathology
Reinforcement
resting state fMRI
Reward
Seeds
Young Adult
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Summary:Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder‐specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting‐state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward‐ to habit‐ oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p 
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.24402