Toward the development of true “off‐the‐shelf” synthetic T‐cell immunotherapy

Recent outstanding clinical results produced by engineered T cells, including chimeric antigen receptors, have already facilitated further research that broadens their applicability. One such direction is to explore new T cell sources for allogeneic “off‐the‐shelf” adoptive immunotherapy. Human plur...

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Bibliographic Details
Published in:Cancer science 2019-01, Vol.110 (1), p.16-22
Main Authors: Iriguchi, Shoichi, Kaneko, Shin
Format: Article
Language:English
Subjects:
Adoptive immunotherapy
antigen specificity
Antigens
Banks
Cancer therapies
Cell Differentiation - immunology
Cell Engineering - methods
Chimeric antigen receptors
Clinical trials
Cytotoxicity
Humans
Immunotherapy
Immunotherapy, Adoptive - methods
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - immunology
iPS cell
Lymphocytes
Lymphocytes T
Manufacturing
Neoplasms - immunology
Neoplasms - therapy
Patients
Pluripotency
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - immunology
regenerative immunotherapy
Researchers
Review
Stem cells
T cell differentiation
T cell rejuvenation
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
T-Lymphocytes - transplantation
Transplantation, Homologous
Vectors (Biology)
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Summary:Recent outstanding clinical results produced by engineered T cells, including chimeric antigen receptors, have already facilitated further research that broadens their applicability. One such direction is to explore new T cell sources for allogeneic “off‐the‐shelf” adoptive immunotherapy. Human pluripotent stem cells could serve as an alternative cell source for this purpose due to their unique features of infinite propagation ability and pluripotency. Here, we describe the current state of engineered T cell transfer with the focus on cell manufacturing processes and the potentials and challenges of induced pluripotent stem cell‐derived T cells as a starting material to construct off‐the‐shelf T‐cell banks. Key steps for differentiation of T cells from hematopoietic pluripotent stem cells. The steps can be divided into three stages: (i) hematopoietic induction; (ii) T cell differentiation; and (iii) T cell maturation. Each stage can be subdivided into several steps.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.13892