Taking Precise Aim at Lung Disease

[...]the more fitting terminology "precision health." To be suitable for use in routine clinical practice, biomarkers must be easy and quick to obtain, relatively inexpensive, minimally invasive, and reproducible across various treatments and populations. [...]biomarkers should be physiolo...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2019-02, Vol.199 (3), p.255-256
Main Author: Piedimonte, Giovanni
Format: Article
Language:English
Subjects:
Accuracy
Asthma
Biomarkers
Bronchioles
Chronic obstructive pulmonary disease
Clinical outcomes
Clinical trials
Epithelial Cells
Humans
Lung diseases
Lung Neoplasms
Medicine
Population
Protein Deficiency
Proteins
Respiratory Physiological Phenomena
Taxonomy
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Summary:[...]the more fitting terminology "precision health." To be suitable for use in routine clinical practice, biomarkers must be easy and quick to obtain, relatively inexpensive, minimally invasive, and reproducible across various treatments and populations. [...]biomarkers should be physiologically relevant to the disease condition and able to predict relevant clinical outcomes with high accuracy. Surprisingly, inflammatory cells, proinflammatory cytokines, mucin production, and other factors strongly associated with airway remodeling- especially transforming growth factor-ß-were not increased in the airways of CC16-deficient mice, which casts some doubt on the suitability of the mouse model to recapitulate mechanisms at work in humans with obstructive lung disease. Something that works in the Tucson Children's Respiratory Study cohort may very well not be useful in other populations. [...]the results and conclusions of this study need to be replicated in subjects from diverse racial, sex, age, and environmental categories, and normative benchmarks need to be generated before CC16 can be considered for use in routine clinical practice.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201811-2117ED