ART adherence and viral suppression are high among most non‐pregnant individuals with early‐stage, asymptomatic HIV infection: an observational study from Uganda and South Africa

Introduction The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS‐free generation depend on high adherence in individuals initiating ART during early‐stage HIV infection; however, adherence may be difficult in the absence of illness and associated support. Methods...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the International AIDS Society 2019-02, Vol.22 (2), p.e25232-n/a
Main Authors: Haberer, Jessica E, Bwana, Bosco M, Orrell, Catherine, Asiimwe, Stephen, Amanyire, Gideon, Musinguzi, Nicholas, Siedner, Mark J, Matthews, Lynn T, Tsai, Alexander C, Katz, Ingrid T, Bell, Kathleen, Kembabazi, Annet, Mugisha, Stephen, Kibirige, Victoria, Cross, Anna, Kelly, Nicola, Hedt‐Gauthier, Bethany, Bangsberg, David R
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
adherence
Adult
AIDS
Analysis
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
antiretroviral therapy
Asymptomatic Diseases - epidemiology
Asymptomatic Diseases - psychology
Asymptomatic Diseases - therapy
Care and treatment
Clinics
Conspiracy
Disease transmission
Drug resistance
Drug therapy
Female
Highly active antiretroviral therapy
HIV
HIV infection
HIV infections
HIV Infections - drug therapy
HIV Infections - psychology
HIV Infections - virology
HIV-1 - drug effects
HIV-1 - physiology
Human immunodeficiency virus
Humans
Infections
Male
Medication Adherence
Observational studies
Patient compliance
Patient outcomes
Pregnancy
Pregnant Women
Prevention
Social networks
Social support
South Africa - epidemiology
stage of disease
Statistics
Stigma
Studies
sub‐Saharan Africa
Uganda - epidemiology
Viral Load
Womens health
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS‐free generation depend on high adherence in individuals initiating ART during early‐stage HIV infection; however, adherence may be difficult in the absence of illness and associated support. Methods From March 2015 to October 2017, we prospectively observed three groups initiating ART in routine care in Uganda and South Africa: men and non‐pregnant women with early‐stage HIV infection (CD4 > 350 cells/μL), pregnant women with early‐stage HIV infection and men and non‐pregnant women with late‐stage HIV infection (CD4  0.72). In South Africa, median adherence was higher in early/non‐pregnant versus early/pregnant or late/non‐pregnant participants (76%, 37%, 52%; p 
ISSN:1758-2652
1758-2652
DOI:10.1002/jia2.25232