Aspergillus-related pulmonary diseases in lung transplantation

While lung transplantation is an attractive treatment option for many end stage lung diseases, the relatively high 5-year mortality continues to be a significant limiting factor. Among the foremost reasons for this is the eventual development of obstructive chronic lung allograft dysfunction. Infect...

Full description

Saved in:
Bibliographic Details
Published in:Medical mycology (Oxford) 2017-01, Vol.55 (1), p.96-102
Main Authors: Pasupneti, S, Manouvakhova, O, Nicolls, M R, Hsu, J L
Format: Article
Language:English
Subjects:
Aspergillus - isolation & purification
Humans
Lung Transplantation
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Postoperative Complications - therapy
Pulmonary Aspergillosis - epidemiology
Pulmonary Aspergillosis - prevention & control
Pulmonary Aspergillosis - therapy
Review
Transplant Recipients
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:While lung transplantation is an attractive treatment option for many end stage lung diseases, the relatively high 5-year mortality continues to be a significant limiting factor. Among the foremost reasons for this is the eventual development of obstructive chronic lung allograft dysfunction. Infections, which the lung allograft is especially prone to, are a major risk factor. Specifically, the Aspergillus species cause a higher burden of disease among lung transplant recipients, due to unique risk factors, such as relative hypoxemia. However, these risk factors also provide unique opportunities for treatment and preventative strategies, as outlined in this review.
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myw121