Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans

Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses would be increased by passive heat stress, as well as exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult....

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2019-02, Vol.316 (2), p.R145-R156
Main Authors: Borgman, Matthew A, Zaar, Morten, Aden, James K, Schlader, Zachary J, Gagnon, Daniel, Rivas, Eric, Kern, Jena, Koons, Natalie J, Convertino, Victor A, Cap, Andrew P, Crandall, Craig
Format: Article
Language:English
Subjects:
Adult
Arterial Pressure - physiology
Bleeding
Coagulation factors
Dehydration
Dehydration - physiopathology
Environmental conditions
Exercise - physiology
Factor V
Fever
Fibrinolysis
Heat stress
Heat Stress Disorders - physiopathology
Heat tolerance
Heat-Shock Response - physiology
Hemorrhage
Hemorrhage - physiopathology
Hemostasis
Hemostasis - physiology
Hemostatics
Hot Temperature - adverse effects
Humans
Hyperthermia
Hyperthermia, Induced - methods
Hypovolemia
Hypovolemia - physiopathology
Lower Body Negative Pressure - methods
Lysis
Male
Thrombocytosis
Trauma
Von Willebrand factor
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Summary:Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses would be increased by passive heat stress, as well as exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to presyncope. In aim 2 subjects exercised in hyperthermic environmental conditions, with and without accompanying dehydration, each also followed by progressive LBNP to presyncope. At baseline, pre-LBNP, and post-LBNP (
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.00223.2018