Sepsis Increases Muscle Proteolysis in Severely Burned Adults, but Does not Impact Whole-Body Lipid or Carbohydrate Kinetics

ABSTRACTSepsis is a common and often fatal consequence of severe burn injury, but its exact effects on whole body and muscle metabolism in the burn patient is unclear. To address this, 13 septic and 11 nonseptic patients (age36.9 ± 13.0 years) with burns encompassing >30% of their total body surf...

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Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2019-09, Vol.52 (3), p.353-361
Main Authors: Murton, Andrew, Bohanon, Fredrick J, Ogunbileje, John O, Capek, Karel D, Tran, Ellen A, Chao, Tony, Sidossis, Labros S, Porter, Craig, Herndon, David N
Format: Article
Language:English
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Summary:ABSTRACTSepsis is a common and often fatal consequence of severe burn injury, but its exact effects on whole body and muscle metabolism in the burn patient is unclear. To address this, 13 septic and 11 nonseptic patients (age36.9 ± 13.0 years) with burns encompassing >30% of their total body surface area underwent muscle protein kinetic studies under postabsorptive conditions using bolus injections of ring-C6 and N phenylalanine isotopes. In parallel, whole-body lipid and carbohydrate kinetics were assessed using constant infusions of [U-C6]palmitate, [6,6-H2]glucose, and [H5]glycerol, and during a 2-h hyperinsulinemic euglycemic clamp. Muscle mRNA levels of genes implicated in the development of muscle cachexia were assessed by qPCR. Fractional breakdown rates of mixed-muscle proteins were found to be 2.4-fold greater in septic versus nonseptic patients (P 
ISSN:1073-2322
1540-0514
DOI:10.1097/SHK.0000000000001263