A Rapid and Robust Diagnostic for Liver Fibrosis Using a Multichannel Polymer Sensor Array

Liver disease is the fifth most common cause of premature death in the Western world, with the irreversible damage caused by fibrosis, and ultimately cirrhosis, a primary driver of mortality. Early detection of fibrosis would facilitate treatment of the underlying liver disease to limit progression....

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2018-07, Vol.30 (28), p.e1800634-n/a
Main Authors: Peveler, William J., Landis, Ryan F., Yazdani, Mahdieh, Day, James W., Modi, Raakesh, Carmalt, Claire J., Rosenberg, William M., Rotello, Vincent M.
Format: Article
Language:English
Subjects:
arrays
Biomarkers
Biopsy
Diagnostic systems
Disease control
Elasticity Imaging Techniques
Fibrosis
Fluorescence
fluorescent polymers
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - diagnosis
Liver diseases
liver fibrosis
Materials science
multichannels
point of care
Polymers
Sensitivity and Specificity
Sensor arrays
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Summary:Liver disease is the fifth most common cause of premature death in the Western world, with the irreversible damage caused by fibrosis, and ultimately cirrhosis, a primary driver of mortality. Early detection of fibrosis would facilitate treatment of the underlying liver disease to limit progression. Unfortunately, most cases of liver disease are diagnosed late, with current strategies reliant on invasive biopsy or fragile lab‐based antibody technologies. A robust, fully synthetic fluorescent‐polymer sensor array is reported, which, rapidly (in 45 minutes), detects liver fibrosis from low‐volume serum samples with clinically relevant specificity and accuracy, using an easily readable diagnostic output. The simplicity, rapidity, and robustness of this method make it a promising platform for point‐of‐care diagnostics for detecting and monitoring liver disease. A fluorescent‐polymer‐based sensor array, capable of distinguishing patients with and without liver fibrosis from a small volume of serum is demonstrated. The robust sensor operates in minutes rather than hours and does not require the cold‐chain transport and storage of the existing antibody‐based techniques, making it an excellent candidate for translation into a point‐of‐care diagnostic tool.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201800634