CD4/CD8 Double-negative Mycosis Fungoides : A Case Report and Literature Review

[ABSTRACT] Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, displays a broad spectrum of clinical, histological and phenotypic variants with different prognostic impacts. The classic immunophenotype is CD3+/CD4+/CD45RO+memory T cells. CD4/CD8 double-negative mycosis fungoides...

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Bibliographic Details
Published in:YONAGO ACTA MEDICA 2019, Vol.62 (1), p.153-158
Main Authors: Ito, Ayako, Sugita, Kazunari, Ikeda, Ayano, Yamamoto, Osamu
Format: Article
Language:English
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Patient Report
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Summary:[ABSTRACT] Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, displays a broad spectrum of clinical, histological and phenotypic variants with different prognostic impacts. The classic immunophenotype is CD3+/CD4+/CD45RO+memory T cells. CD4/CD8 double-negative mycosis fungoides is rare. Here we describe the clinicopathological features of CD4/CD8 double-negative mycosis fungoides in a 55-year-old female with a review of the literature. Although the CD4/CD8 double-negative phenotype appears to be associated with an unusual clinical presentation, it does not appear to confer prognostic significance.
ISSN:0513-5710
1346-8049
DOI:10.33160/yam.2019.03.021