The role of CD32 during HIV-1 infection

Persistence of latent HIV-1 in long-lived resting memory CD4+ T cells is a major barrier to curing HIV-1 infection, and thus a biomarker for latently infected cells would be of great scientific and clinical importance. 1 , 2 , 3 , 4 , 5 Through an elegant discovery-based approach, Descours et al . r...

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Bibliographic Details
Published in:Nature (London) 2018-09, Vol.561 (7723), p.E17-E19
Main Authors: Bertagnolli, Lynn N., White, Jennifer A., Simonetti, Francesco R., Beg, Subul A., Lai, Jun, Tomescu, Costin, Murray, Alexandra J., Antar, Annukka A. R., Zhang, Hao, Margolick, Joseph B., Hoh, Rebecca, Deeks, Stephen G., Tebas, Pablo, Montaner, Luis J., Siliciano, Robert F., Laird, Gregory M., Siliciano, Janet D.
Format: Article
Language:English
Subjects:
13/106
13/31
631/326/2521
631/326/596/1787
Biological markers
Brief Communications Arising
Fc receptors
HIV
HIV infections
Humanities and Social Sciences
Medical schools
multidisciplinary
Science
Science (multidisciplinary)
T cells
Universities and colleges
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Summary:Persistence of latent HIV-1 in long-lived resting memory CD4+ T cells is a major barrier to curing HIV-1 infection, and thus a biomarker for latently infected cells would be of great scientific and clinical importance. 1 , 2 , 3 , 4 , 5 Through an elegant discovery-based approach, Descours et al . reported that CD32a, an Fcγ receptor not normally expressed on T cells, is a potential biomarker for latently infected cells. 6 Using the quantitative viral outgrowth assay, we show that CD32+ CD4+ T cells do not harbor the majority of intact proviruses in the latent reservoir and that the enrichment found by Descours et al . may in part reflect the use of an ultrasensitive ELISA for HIV-1 p24 antigen that does not predict exponential viral outgrowth. Our studies show that CD32 is not a biomarker for the major population of latently infected CD4+ T cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/s41586-018-0494-3