Whether Keratectasia Area Shown in Corneal Topography Is Appropriate for Evaluating the Effect of Corneal Cross-Linking for Keratoconus: A 12-Month Follow-Up Study

Purpose. To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods. A retrospective analysis was conducted in 34 eye...

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Published in:BioMed research international 2019-01, Vol.2019 (2019), p.1-5
Main Authors: Gao, Ning, Zhang, Huankai, Li, Zhiwei, Wang, Jia, Mu, Guo-ying
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cataracts
Cell density
Child
Collagen
Contact lenses
Cornea
Cornea - physiopathology
Cornea - surgery
Cornea - ultrastructure
Corneal Topography - methods
Crosslinking
Endothelial cells
Epithelium, Corneal - growth & development
Epithelium, Corneal - pathology
Eye (anatomy)
Female
Follow-Up Studies
Humans
Keratectomy - methods
Keratoconus
Keratoconus - physiopathology
Keratoconus - surgery
Male
Patients
Pharmaceutical industry
Photochemotherapy
Physiology
Regression analysis
Regression models
Software
Statistical analysis
Surgery
Tomography
Topography
Visual Acuity
Vitamin B
Young Adult
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Zhang, Huankai
Li, Zhiwei
Wang, Jia
Mu, Guo-ying
description Purpose. To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods. A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with K-value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (K1, K2, and Kmax), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including Kmax and TCT, was analyzed. Results. Linear regression model revealed the KEA, Kmax, K1, and K2 decreased after CXL in model y = 0.9622 -0.02408 x (P
doi_str_mv 10.1155/2019/1762537
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To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods. A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with K-value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (K1, K2, and Kmax), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including Kmax and TCT, was analyzed. Results. Linear regression model revealed the KEA, Kmax, K1, and K2 decreased after CXL in model y = 0.9622 -0.02408 x (P&lt;0.05), y = 0.9982 -0.003469 x(P&lt;0.05), y = 0.9977 + -0.001347 x(P&lt;0.05), y = 0.9992 + -0.001779 x(P&lt;0.05) (y represents KEA, Kmax, K1, or K2; x represents time (month)). The KEA is significantly decreased in early stage (before month 3) (P&lt;0.05); however, the Kmax, K1, and K2 have no significant decrease in early stage (P= 0.09, 0.19, 0.32). Conclusions. The KEA is more sensitive than K-value in describing the morphological changes of cornea after CXL, especially in early stage after treatment.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/1762537</identifier><identifier>PMID: 31073520</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Adult ; Cataracts ; Cell density ; Child ; Collagen ; Contact lenses ; Cornea ; Cornea - physiopathology ; Cornea - surgery ; Cornea - ultrastructure ; Corneal Topography - methods ; Crosslinking ; Endothelial cells ; Epithelium, Corneal - growth &amp; development ; Epithelium, Corneal - pathology ; Eye (anatomy) ; Female ; Follow-Up Studies ; Humans ; Keratectomy - methods ; Keratoconus ; Keratoconus - physiopathology ; Keratoconus - surgery ; Male ; Patients ; Pharmaceutical industry ; Photochemotherapy ; Physiology ; Regression analysis ; Regression models ; Software ; Statistical analysis ; Surgery ; Tomography ; Topography ; Visual Acuity ; Vitamin B ; Young Adult</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-5</ispartof><rights>Copyright © 2019 Jia Wang et al.</rights><rights>COPYRIGHT 2019 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2019 Jia Wang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods. A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with K-value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (K1, K2, and Kmax), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including Kmax and TCT, was analyzed. Results. 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To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods. A retrospective analysis was conducted in 34 eyes from 24 progressive KC patients who have underwent CXL from 2015 to 2017. Area with K-value more than 47D shown in the corneal topography was marked and identified as KEA. Keratometry (K1, K2, and Kmax), KEA, thinnest corneal thickness (TCT), and endothelial cell density (ECD) were evaluated preoperatively or at months 3, 6, and 12 postoperatively. The changes of KEA before and after operation were evaluated. The relation of KEA and other parameters, including Kmax and TCT, was analyzed. Results. Linear regression model revealed the KEA, Kmax, K1, and K2 decreased after CXL in model y = 0.9622 -0.02408 x (P&lt;0.05), y = 0.9982 -0.003469 x(P&lt;0.05), y = 0.9977 + -0.001347 x(P&lt;0.05), y = 0.9992 + -0.001779 x(P&lt;0.05) (y represents KEA, Kmax, K1, or K2; x represents time (month)). The KEA is significantly decreased in early stage (before month 3) (P&lt;0.05); however, the Kmax, K1, and K2 have no significant decrease in early stage (P= 0.09, 0.19, 0.32). Conclusions. The KEA is more sensitive than K-value in describing the morphological changes of cornea after CXL, especially in early stage after treatment.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31073520</pmid><doi>10.1155/2019/1762537</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0012-2385</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Cataracts
Cell density
Child
Collagen
Contact lenses
Cornea
Cornea - physiopathology
Cornea - surgery
Cornea - ultrastructure
Corneal Topography - methods
Crosslinking
Endothelial cells
Epithelium, Corneal - growth & development
Epithelium, Corneal - pathology
Eye (anatomy)
Female
Follow-Up Studies
Humans
Keratectomy - methods
Keratoconus
Keratoconus - physiopathology
Keratoconus - surgery
Male
Patients
Pharmaceutical industry
Photochemotherapy
Physiology
Regression analysis
Regression models
Software
Statistical analysis
Surgery
Tomography
Topography
Visual Acuity
Vitamin B
Young Adult
title Whether Keratectasia Area Shown in Corneal Topography Is Appropriate for Evaluating the Effect of Corneal Cross-Linking for Keratoconus: A 12-Month Follow-Up Study
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