Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease

• Published in: International journal of cardiology 2019-04, Vol.281, p.15-21
• Main Authors: Grande Gutierrez, Noelia, Mathew, Mathew, McCrindle, Brian W., Tran, Justin S., Kahn, Andrew M., Burns, Jane C., Marsden, Alison L.
• Format: Article
• Language: English
• Subjects: Adolescent; Aneurysm; Child; Child, Preschool; Computational modeling; Coronary Aneurysm - diagnostic imaging; Coronary Aneurysm - physiopathology; Female; Hemodynamics; Hemodynamics - physiology; Humans; Imaging, Three-Dimensional - methods; Infant; Kawasaki disease; Magnetic resonance imaging; Magnetic Resonance Imaging, Cine - methods; Male; Mucocutaneous Lymph Node Syndrome - diagnostic imaging; Mucocutaneous Lymph Node Syndrome - physiopathology; Retrospective Studies; Thrombosis; Thrombosis - diagnostic imaging; Thrombosis - physiopathology
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2019.01.092

Thrombosis is a major adverse outcome associated with coronary artery aneurysms (CAAs) resulting from Kawasaki disease (KD). Clinical guidelines recommend initiation of anticoagulation therapy with maximum CAA diameter (Dmax) ≥8 mm or Z-score ≥ 10. Here, we investigate the role of aneurysm hemodynamics as a superior method for thrombotic risk stratification in KD patients. We retrospectively studied ten KD patients with CAAs, including five patients who developed thrombosis. We constructed patient-specific anatomic models from cardiac magnetic resonance images and performed computational hemodynamic simulations using SimVascular. Our simulations incorporated pulsatile flow, deformable arterial walls and boundary conditions automatically tuned to match patient-specific arterial pressure and cardiac output. From simulation results, we derived local hemodynamic variables including time-averaged wall shear stress (TAWSS), low wall shear stress exposure, and oscillatory shear index (OSI). Local TAWSS was significantly lower in CAAs that developed thrombosis (1.2 ± 0.94 vs. 7.28 ± 9.77 dynes/cm2, p = 0.006) and the fraction of CAA surface area exposed to low wall shear stress was larger (0.69 ± 0.17 vs. 0.25 ± 0.26%, p = 0.005). Similarly, longer residence times were obtained in branches where thrombosis was confirmed (9.07 ± 6.26 vs. 2.05 ± 2.91 cycles, p = 0.004). No significant differences were found for OSI or anatomical measurements such us Dmax and Z-score. Assessment of thrombotic risk according to hemodynamic variables had higher sensitivity and specificity compared to standard clinical metrics (Dmax, Z-score). Hemodynamic variables can be obtained non-invasively via simulation and may provide improved thrombotic risk stratification compared to current diameter-based metrics, facilitating long-term clinical management of KD patients with persistent CAAs. •Computational simulations provide patient specific hemodynamics non-invasively.•Hemodynamic variables are superior to anatomical measurements for KD aneurysms assessment.•Local hemodynamic variables identify aneurysmal regions at higher risk of thrombosis.•Patient thrombotic risk stratification was improved using hemodynamic variables.•Hemodynamic variables may improve clinical decision-making regarding anticoagulation therapy.