Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA

Bulky organic carcinogens are activated in vivo and subsequently react with nucleobases of cellular DNA to produce adducts. Some of these DNA adducts exist in multiple conformations that are slowly interconverted to one another. Different conformations have been implicated in different mutagenic and...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-04, Vol.24 (8), p.1566
Main Authors: Cai, Ang, Bian, Ke, Chen, Fangyi, Tang, Qi, Carley, Rachel, Li, Deyu, Cho, Bongsup P.
Format: Article
Language:English
Subjects:
4-aminobiphenyl
Bladder
bulky DNA lesion
conformational heterogeneity
Efficiency
Enzyme kinetics
Experiments
Klenow fragment
Lesions
Mutation
steady state enzyme kinetics
surface plasmon resonance (SPR) binding kinetics
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