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secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epith...
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| Published in: | Scientific reports 2019-05, Vol.9 (1), p.7464, Article 7464 |
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| creator | Feingold, Daniel Knogler, Laura Starc, Tanja Drapeau, Pierre O’Donnell, Michael J. Nilson, Laura A. Dent, Joseph A. |
| description | Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion. |
| doi_str_mv | 10.1038/s41598-019-42849-9 |
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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feingold, Daniel</au><au>Knogler, Laura</au><au>Starc, Tanja</au><au>Drapeau, Pierre</au><au>O’Donnell, Michael J.</au><au>Nilson, Laura A.</au><au>Dent, Joseph A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-05-16</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>7464</spage><pages>7464-</pages><artnum>7464</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. 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| subjects | 13/51 14/1 14/10 14/35 42/109 631/181/735 631/443/376 64/24 9/74 Animals Chloride Chloride Channels - chemistry Chloride Channels - genetics Chloride Channels - metabolism Chloride conductance Chlorides - metabolism Dehydration Diuretics Drosophila melanogaster Drosophila Proteins - metabolism Epithelial cells Epithelium - metabolism Excretion G protein-coupled receptors Hormones Humanities and Social Sciences Insect Hormones - metabolism Ion Channel Gating Ion channels Ion Transport Malpighian Tubules - metabolism Membrane permeability multidisciplinary Neurotransmission Osmolarity Osmoregulation Permeability Protein Domains Science Science (multidisciplinary) Secretion Water balance Xenopus |
| title | secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila |
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