The Synthetic Phenotype of Δ bamB Δ bamE Double Mutants Results from a Lethal Jamming of the Bam Complex by the Lipoprotein RcsF

The selective permeability of the Gram-negative outer membrane (OM) is maintained by integral β-barrel outer membrane proteins (OMPs). The heteropentomeric β-barrel assembly machine (Bam) folds and inserts OMPs into the OM. Coordination of the essential proteins BamA and BamD is critical for OMP ass...

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Bibliographic Details
Published in:mBio 2019-05, Vol.10 (3)
Main Authors: Hart, Elizabeth M, Gupta, Meera, Wühr, Martin, Silhavy, Thomas J
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - metabolism
Biosynthesis
Cell surface
Defects
Efficiency
Escherichia coli - metabolism
Escherichia coli Proteins - genetics
Escherichia coli Proteins - metabolism
Evolution
Gene Deletion
Genetic suppression
Gram-negative bacteria
Lipid bilayers
Lipoproteins
Lipoproteins - metabolism
Membrane permeability
Microbial Viability
Molecular Biology and Physiology
Mutants
Mutation
Outer membrane proteins
Phenotypes
Protein expression
Protein Multimerization
Proteins
Proteomes
Proteomics
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