Evaluation of the efficacy and safety of Capsule Longvida ® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study

• Published in: Journal of inflammation research 2019-01, Vol.12, p.145-152
• Main Authors: Gupte, Poonam Ashish, Giramkar, Shital Ashok, Harke, Shubhangi Mandar, Kulkarni, Sneha Keshav, Deshmukh, Amol Panjabrao, Hingorani, Lal Lachhmandas, Mahajan, Madhavi Prabhakar, Bhalerao, Supriya Sudhakar
• Format: Article
• Language: English
• Subjects: Original Research
• ISSN: 1178-7031; 1178-7031
• DOI: 10.2147/JIR.S205390

Osteoarthritis is the single most common cause of disability in older adults with an estimated 10% to 15% prevalence in individuals above 60 years. The contemporary medications include nonsteroidal anti-inflammatory drugs acetaminophen, cyclooxygenase-2 inhibitors, and surgical interventions. In view of safety issues regarding their longterm use, necessitating search for effective and safe alternatives, we evaluated Capsule Longvida Optimized Curcumin prepared using solid lipid curcumin particles (SLCP) technology in patients with knee osteoarthritis. Eligible patients fulfilling American College of Rheumatology Criteria were randomized to SLCP group (400 mg twice daily delivering 80 mg of curcumin per capsule) or Ibuprofen with placebo group (400 mg each once daily) for 90 days. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Visual Analog Scale (VAS) were used for clinical assessment of knee pain and function. Degree of knee flexion and swelling were also noted. Blood biochemistry included hemogram, blood urea, creatinine, Random blood sugar and inflammatory markers viz. PGE2, TNF α, IL6, IL1β and LTB4 while urine examination included degenerative marker CTX II. The parametric data was analyzed using unpaired test while non-parametric data was analyzed using Friedman's test or Mann Whitney test as applicable. A level of