Methodological considerations for studies of brain glycogen

Glycogen stores in the brain have been recognized for decades, but the underlying physiological function of this energy reserve remains elusive. This uncertainty stems in part from several technical challenges inherent in the study of brain glycogen metabolism. These include low glycogen content in...

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Bibliographic Details
Published in:Journal of neuroscience research 2019-08, Vol.97 (8), p.914-922
Main Authors: Wu, Long, Wong, Candance P., Swanson, Raymond A.
Format: Article
Language:English
Subjects:
astrocytes
Brain
energy metabolism
Energy reserves
Glycogen
Metabolism
Radioactive tracers
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Summary:Glycogen stores in the brain have been recognized for decades, but the underlying physiological function of this energy reserve remains elusive. This uncertainty stems in part from several technical challenges inherent in the study of brain glycogen metabolism. These include low glycogen content in the brain, non‐homogeneous labeling of glycogen by radiotracers, rapid glycogenolysis during postmortem tissue handling, and effects of the stress response on brain glycogen turnover. Here we briefly review the aspects of the glycogen structure and metabolism that bear on these technical challenges and present ways they can be addressed.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.24412