Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells

Zika virus (ZIKV) and Dengue virus (DENV) are mosquito-borne viruses of the genus that could cause congenital microcephaly and hemorrhage, respectively, in humans, and thus present a risk to global public health. A preventive vaccine against ZIKV remains unavailable, and no specific antiviral drugs...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-05, Vol.20 (10), p.2382
Main Authors: Haddad, Juliano G, Koishi, Andrea Cristine, Gaudry, Arnaud, Nunes Duarte Dos Santos, Claudia, Viranaicken, Wildriss, Desprès, Philippe, El Kalamouni, Chaker
Format: Article
Language:English
Subjects:
Antiviral activity
Cell lines
Chemical Sciences
Clinical isolates
Congenital defects
Cytotoxicity
Dengue fever
Disease transmission
Epidemics
Flow cytometry
Herbal medicine
Infections
Infectivity
Life Sciences
Medicinal Chemistry
Microbiology and Parasitology
Neurological diseases
Phytochemicals
Plant extracts
Polyphenols
Progeny
Public health
Serotypes
Titration
Virology
Zika virus
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Summary:Zika virus (ZIKV) and Dengue virus (DENV) are mosquito-borne viruses of the genus that could cause congenital microcephaly and hemorrhage, respectively, in humans, and thus present a risk to global public health. A preventive vaccine against ZIKV remains unavailable, and no specific antiviral drugs against ZIKV and DENV are licensed. Medicinal plants may be a source of natural antiviral drugs which mostly target viral entry. In this study, we evaluate the antiviral activity of , an indigenous medicinal plant from the Mascarene Islands, against ZIKV and DENV infection. Our data indicated that exhibited potent antiviral activity against a contemporary epidemic strain of ZIKV and clinical isolates of four DENV serotypes at non-cytotoxic concentrations in human cells. Time-of-drug-addition assays revealed that extract acts on ZIKV entry by preventing the internalisation of virus particles into the host cells. Our data suggest that -mediated ZIKV inhibition relates to virus particle inactivation. We suggest that could be a promising natural source for the development of potential antivirals against medically important flaviviruses.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20102382