Learning to Identify Patients at Risk of Uncontrolled Hypertension Using Electronic Health Records Data

• Published in: AMIA Summits on Translational Science proceedings 2019, Vol.2019, p.533-542
• Main Authors: Mohammadi, Ramin, Jain, Sarthak, Agboola, Stephen, Palacholla, Ramya, Kamarthi, Sagar, Wallace, Byron C
• Format: Article
• Language: English
• ISSN: 2153-4063; 2153-4063

Hypertension is a major risk factor for stroke, cardiovascular disease, and end-stage renal disease, and its prevalence is expected to rise dramatically. Effective hypertension management is thus critical. A particular priority is decreasing the incidence of uncontrolled hypertension. Early identification of patients at risk for uncontrolled hypertension would allow targeted use of personalized, proactive treatments. We develop machine learning models (logistic regression and recurrent neural networks) to stratify patients with respect to the risk of exhibiting uncontrolled hypertension within the coming three-month period. We trained and tested models using EHR data from 14,407 and 3,009 patients, respectively. The best model achieved an AUROC of 0.719, outperforming the simple, competitive baseline of relying prediction based on the last BP measure alone (0.634). Perhaps surprisingly, recurrent neural networks did not outperform a simple logistic regression for this task, suggesting that linear models should be included as strong baselines for predictive tasks using EHR.