Volatile organic compounds emitted from faeces as a biomarker for colorectal cancer

Summary Background Colorectal cancer remains a leading cause of mortality and morbidity. The UK Bowel Cancer Screening Programme (BCSP) has demonstrated that detection of colorectal cancer at an earlier stage and identification of advanced pre‐malignant adenomas reduces mortality and morbidity. Aim...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2019-04, Vol.49 (8), p.1005-1012
Main Authors: Bond, Ashley, Greenwood, Rosemary, Lewis, Stephen, Corfe, Bernard, Sarkar, Sanchoy, O'Toole, Paul, Rooney, Paul, Burkitt, Michael, Hold, Georgina, Probert, Chris
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenomatous Polyps - diagnosis
Adult
Aged
Aged, 80 and over
Biomarkers
Biomarkers, Tumor - analysis
Cancer screening
Colonoscopy
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Early Detection of Cancer - methods
Faecal Volatile Compounds as a Biomarker for Colorectal Neoplasia
Feces
Feces - chemistry
Female
Gas chromatography
Gas Chromatography-Mass Spectrometry
Headspace
Humans
Intestine
Male
Mass Screening - methods
Mass spectrometry
Mass spectroscopy
Medical screening
Middle Aged
Morbidity
Mortality
Organic compounds
Original
Regression analysis
Sensitivity and Specificity
VOCs
Volatile organic compounds
Volatile Organic Compounds - analysis
Young Adult
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Summary:Summary Background Colorectal cancer remains a leading cause of mortality and morbidity. The UK Bowel Cancer Screening Programme (BCSP) has demonstrated that detection of colorectal cancer at an earlier stage and identification of advanced pre‐malignant adenomas reduces mortality and morbidity. Aim To assess the utility of volatile organic compounds as a biomarker for colorectal neoplasia. Methods Faeces were collected from symptomatic patients and people participating in the UK BCSP, prior to colonoscopy. Headspace extraction followed by gas chromatography mass spectrometry was performed on faeces to identify volatile organic compounds. Logistic regression modelling and 10‐fold cross‐validation were used to test potential biomarkers. Results One hundred and thirty‐seven participants were included (mean age 64 years [range 22‐85], 54% were male): 60 had no neoplasia, 56 had adenomatous polyp(s) and 21 had adenocarcinoma. Propan‐2‐ol was significantly more abundant in the cancer samples (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.15140