Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets

Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season only. To better understand potential mechanisms underlying these observations, we vaccinated infl...

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Bibliographic Details
Published in:npj vaccines 2019-07, Vol.4 (1), p.28, Article 28
Main Authors: Music, Nedzad, Tzeng, Wen-Pin, Liaini Gross, F., Levine, Min Z., Xu, Xiyan, Shieh, Wun-Ju, Tumpey, Terrence M., Katz, Jacqueline M., York, Ian A.
Format: Article
Language:English
Subjects:
631/250/2152
631/250/590
631/326/596/1578
Biomedical and Life Sciences
Biomedicine
Immunization
Infectious Diseases
Influenza
Laboratory animals
Medical Microbiology
Public Health
Vaccine
Vaccines
Viral infections
Virology
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Summary:Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season only. To better understand potential mechanisms underlying these observations, we vaccinated influenza-naive ferrets either twice, 10 months apart (repeated vaccination group; RV), or once (current season only group; CS), using a prime-boost regimen, and then challenged the ferrets with A/Hong Kong/4801/2014(H3N2). Ferrets that received either vaccine regimen were protected against influenza disease and infection relative to naive unvaccinated ferrets, but the RV group shed more virus, especially at the peak of virus shedding 2 days post infection ( p  
ISSN:2059-0105
2059-0105
DOI:10.1038/s41541-019-0123-7