A dual‐tuned multichannel bilateral RF coil for 1H/23Na breast MRI at 7 T

• Published in: Magnetic resonance in medicine 2019-10, Vol.82 (4), p.1566-1575
• Main Authors: Ianniello, Carlotta, Madelin, Guillaume, Moy, Linda, Brown, Ryan
• Format: Article
• Language: English
• Subjects: Arrays; bilateral breast coil; Breast cancer; breast MRI; Chemotherapy; Excitation; high‐field MRI; Image acquisition; Magnetic resonance imaging; Medical imaging; Metabolism; multi‐nuclei coil; Protons; Signal reception; Sodium; sodium (23Na) MRI
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.27829

Purpose Sodium MRI has shown promise for monitoring neoadjuvant chemotherapy response in breast cancer. The purpose of this work was to build a dual‐tuned bilateral proton/sodium breast coil for 7T MRI that provides sufficient SNR to enable sodium breast imaging in less than 10 minutes. Methods The proton/sodium coil consists of 2 shielded unilateral units: 1 for each breast. Each unit consists of 3 nested layers: (1) a 3‐loop solenoid for sodium excitation, (2) a 3‐loop solenoid for proton excitation and signal reception, and (3) a 4‐channel receive array for sodium signal reception. Benchmark measurements were performed in phantoms with and without the sodium receive array insert. In vivo images were acquired on a healthy volunteer. Results The sodium receive array boosted 1.5 to 3 times the SNR compared with the solenoid. Proton SNR loss due to residual interaction with the sodium array was less than 10%. The coil enabled sodium imaging in vivo with 2.8‐mm isotropic nominal resolution (~5‐mm real resolution) in 9:36 minutes. Conclusion The coil design that we propose addresses challenges associated with sodium's low SNR from a hardware perspective and offers the opportunity to investigate noninvasively breast tumor metabolism as a function of sodium concentration in patients undergoing neoadjuvant chemotherapy.