Chagas' disease: IgG isotypes against cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens of Trypanosoma cruzi in chronic Chagasic patients

The wide range of clinical Chagas' disease manifestations, of which heart involvement is the most significant, because of its characteristics, frequency and consequences, and lack of treatment and cure, justify research in this area. Specific immunoglobulin G (IgG) antibody subclasses have been...

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Published in:Journal of clinical laboratory analysis 2007, Vol.21 (5), p.271-276
Main Authors: Verçosa, A.F.A., Lorena, V.M.B., Carvalho, C.L., Melo, M.F.A.D., Cavalcanti, M.G.A., Silva, E.D., Ferreira, A.G.P., Pereira, V.R.A., Souza, W.V., Gomes, Y.M.
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Antibodies, Protozoan - blood
Antibody Formation
Antigens, Protozoan - blood
biological marker
Chagas Disease - immunology
Chagas' disease
Chronic Disease
Female
Humans
Immunoglobulin G - blood
Immunoglobulin G - classification
isotypic profile
Male
Middle Aged
Original
recombinant antigens
Trypanosoma cruzi
Trypanosoma cruzi - immunology
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Summary:The wide range of clinical Chagas' disease manifestations, of which heart involvement is the most significant, because of its characteristics, frequency and consequences, and lack of treatment and cure, justify research in this area. Specific immunoglobulin G (IgG) antibody subclasses have been associated with human Chagas' disease. Thus, in this study, the profile of IgG subclasses against cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive T. cruzi–specific antigens was correlated with cardiac (CARD, n=33), cardiodigestive (CD, n=7), and indeterminate (IND, n=20) forms of Chagas' disease by indirect enzyme‐linked immunosorbent assay (ELISA). IgG subclasses were detected in almost all Chagas patients studied. Nevertheless, only specific IgG2 isotype FRA was found with a significant statistical difference in CARD patients when compared to IND patients. This result suggests the potential use of this isotype for prognostic purposes, for monitoring the progression of chronic Chagas' disease, and for predicting the risk of CARD damage. This is important information, as it could help physicians to evaluate and manage the treatment of their patients. However, a follow‐up study is necessary to confirm our result. J. Clin. Lab. Anal. 21:271–276, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.20186