Hyperhomocysteinemia in patients with heart failure referred for cardiac transplantation: Preliminary observations

Background: Hyperhomocysteinemia is becoming recognized as a risk factor for cardiovascular disease, yet there are limited data on the prevalence of hyperhomocysteinemia in patients with heart failure. Hypothesis: The purpose of this study was to examine the prevalence of hyperhomocysteinemia in pat...

Full description

Saved in:
Bibliographic Details
Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2003-09, Vol.26 (9), p.407-410
Main Authors: Schofield, Richard S., Wessel, Timothy R., Walker, Tracy C., Cleeton, Timothy S., Hill, James A., Aranda, Juan M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Cardiomyopathies - metabolism
Cardiomyopathies - therapy
Clinical Investigation
Clinical Investigations
Coronary Artery Disease - metabolism
Coronary Artery Disease - therapy
Creatinine - blood
Creatinine - urine
Female
Florida
Folic Acid - therapeutic use
Heart
heart failure
Heart Failure - drug therapy
Heart Failure - metabolism
Heart Failure - surgery
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Heart Transplantation
Hematinics - therapeutic use
homocysteine
Homocysteine - blood
Homocysteine - drug effects
Humans
Hyperhomocysteinemia - drug therapy
Hyperhomocysteinemia - metabolism
Hyperhomocysteinemia - surgery
Male
Medical sciences
Middle Aged
Oxygen Consumption - physiology
Pulmonary Wedge Pressure - physiology
Retrospective Studies
Severity of Illness Index
Statistics as Topic
Stroke Volume - physiology
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Hyperhomocysteinemia is becoming recognized as a risk factor for cardiovascular disease, yet there are limited data on the prevalence of hyperhomocysteinemia in patients with heart failure. Hypothesis: The purpose of this study was to examine the prevalence of hyperhomocysteinemia in patients with severe heart failure and to correlate serum homocysteine levels with factors that may affect homocysteine metabolism. Methods: Serum homocysteine levels were measured at the time of cardiac transplant evaluation in 89 consecutive patients with severe heart failure. Homocysteine levels for patients with ischemic cardiomyopathy (ICM) were compared with levels obtained in patients with nonischemic cardiomyopathy (NICM), and homocysteine levels were correlated with demographic and hemodynamic parameters as well as functional status. Results: The mean plasma homocysteine level was increased (14.3 ± 5.3 μmol/l, normal
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.4960260904