Insulin resistance and maximal oxygen uptake

Background: Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown. Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the...

Full description

Saved in:
Bibliographic Details
Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2003-11, Vol.26 (11), p.515-520
Main Authors: Seibæk, Marie, Vestergaard, Henrik, Burchardt, Hans, Sloth, Carsten, Torp‐Pedersen, Christian, Nielsen, Steen Levin, Hildebrandt, Per, Pedersen, Oluf
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Clinical Investigation
Clinical Investigations
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - physiopathology
Exercise - physiology
Female
Humans
insulin resistance
Insulin Resistance - physiology
Linear Models
Male
maximal oxygen uptake
Medical sciences
Middle Aged
Muscle, Skeletal - metabolism
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Oxygen - metabolism
Physical Fitness
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown. Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the presence of either diabetes or ischemic heart disease. Methods: The study population comprised 33 patients with and without diabetes and ischemic heart disease. Insulin resistance was measured by a hyperinsulinemic euglycemic clamp; maximal oxygen uptake was measured during a bicycle exercise test. Results: There was a strong correlation between maximal oxygen uptake and insulin‐stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease. Conclusion: Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes.
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.4960261107