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Insulin resistance and maximal oxygen uptake
Background: Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown. Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the...
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| Published in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2003-11, Vol.26 (11), p.515-520 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 520 |
| container_issue | 11 |
| container_start_page | 515 |
| container_title | Clinical cardiology (Mahwah, N.J.) |
| container_volume | 26 |
| creator | Seibæk, Marie Vestergaard, Henrik Burchardt, Hans Sloth, Carsten Torp‐Pedersen, Christian Nielsen, Steen Levin Hildebrandt, Per Pedersen, Oluf |
| description | Background: Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown.
Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the presence of either diabetes or ischemic heart disease.
Methods: The study population comprised 33 patients with and without diabetes and ischemic heart disease. Insulin resistance was measured by a hyperinsulinemic euglycemic clamp; maximal oxygen uptake was measured during a bicycle exercise test.
Results: There was a strong correlation between maximal oxygen uptake and insulin‐stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.
Conclusion: Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes. |
| doi_str_mv | 10.1002/clc.4960261107 |
| format | article |
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Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the presence of either diabetes or ischemic heart disease.
Methods: The study population comprised 33 patients with and without diabetes and ischemic heart disease. Insulin resistance was measured by a hyperinsulinemic euglycemic clamp; maximal oxygen uptake was measured during a bicycle exercise test.
Results: There was a strong correlation between maximal oxygen uptake and insulin‐stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.
Conclusion: Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.4960261107</identifier><identifier>PMID: 14640466</identifier><identifier>CODEN: CLCADC</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Clinical Investigation ; Clinical Investigations ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Angiopathies - metabolism ; Diabetic Angiopathies - physiopathology ; Exercise - physiology ; Female ; Humans ; insulin resistance ; Insulin Resistance - physiology ; Linear Models ; Male ; maximal oxygen uptake ; Medical sciences ; Middle Aged ; Muscle, Skeletal - metabolism ; Myocardial Infarction - metabolism ; Myocardial Infarction - physiopathology ; Oxygen - metabolism ; Physical Fitness ; Prospective Studies</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2003-11, Vol.26 (11), p.515-520</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4667-efa5165df8c082dc6004ea6f3a75c3f00ee5417f99e948d0ec531281c59cee0b3</citedby><cites>FETCH-LOGICAL-c4667-efa5165df8c082dc6004ea6f3a75c3f00ee5417f99e948d0ec531281c59cee0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6654563/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6654563/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15270703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14640466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seibæk, Marie</creatorcontrib><creatorcontrib>Vestergaard, Henrik</creatorcontrib><creatorcontrib>Burchardt, Hans</creatorcontrib><creatorcontrib>Sloth, Carsten</creatorcontrib><creatorcontrib>Torp‐Pedersen, Christian</creatorcontrib><creatorcontrib>Nielsen, Steen Levin</creatorcontrib><creatorcontrib>Hildebrandt, Per</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><title>Insulin resistance and maximal oxygen uptake</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Background: Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown.
Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the presence of either diabetes or ischemic heart disease.
Methods: The study population comprised 33 patients with and without diabetes and ischemic heart disease. Insulin resistance was measured by a hyperinsulinemic euglycemic clamp; maximal oxygen uptake was measured during a bicycle exercise test.
Results: There was a strong correlation between maximal oxygen uptake and insulin‐stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.
Conclusion: Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Clinical Investigation</subject><subject>Clinical Investigations</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Angiopathies - metabolism</subject><subject>Diabetic Angiopathies - physiopathology</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Linear Models</subject><subject>Male</subject><subject>maximal oxygen uptake</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Oxygen - metabolism</subject><subject>Physical Fitness</subject><subject>Prospective Studies</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPwzAUhS0EoqWwMqIsMJFynfgRL0go4lGpEgvMluvclICblLiB9t_jqhUtE5MHf_eco4-QcwpDCpDcWGeHTAlIBKUgD0ifqjSJM5nKQ9IHKiBWSaZ65MT798BDlqTHpEeZYMCE6JPrUe07V9VRi77yC1NbjExdRDOzrGbGRc1yNcU66uYL84Gn5Kg0zuPZ9h2Q14f7l_wpHj8_jvK7cWxDpoyxNJwKXpSZDX2FFQAMjShTI7lNSwBEzqgslULFsgLQ8pQmGbVcWUSYpANyu8mdd5MZFhbrRWucnrdhUrvSjan035-6etPT5ksLwRkXaQi42ga0zWeHfqFnlbfonKmx6byWlIECJgM43IC2bbxvsfwtoaDXgnUQrHeCw8HF_rQdvjUagMstYLw1rmyD0srvOJ5IkLCeqDbcd-Vw9U-tzsf53ogfu7uUlw</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Seibæk, Marie</creator><creator>Vestergaard, Henrik</creator><creator>Burchardt, Hans</creator><creator>Sloth, Carsten</creator><creator>Torp‐Pedersen, Christian</creator><creator>Nielsen, Steen Levin</creator><creator>Hildebrandt, Per</creator><creator>Pedersen, Oluf</creator><general>Wiley Periodicals, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200311</creationdate><title>Insulin resistance and maximal oxygen uptake</title><author>Seibæk, Marie ; Vestergaard, Henrik ; Burchardt, Hans ; Sloth, Carsten ; Torp‐Pedersen, Christian ; Nielsen, Steen Levin ; Hildebrandt, Per ; Pedersen, Oluf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4667-efa5165df8c082dc6004ea6f3a75c3f00ee5417f99e948d0ec531281c59cee0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Clinical Investigation</topic><topic>Clinical Investigations</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Angiopathies - metabolism</topic><topic>Diabetic Angiopathies - physiopathology</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Linear Models</topic><topic>Male</topic><topic>maximal oxygen uptake</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Oxygen - metabolism</topic><topic>Physical Fitness</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seibæk, Marie</creatorcontrib><creatorcontrib>Vestergaard, Henrik</creatorcontrib><creatorcontrib>Burchardt, Hans</creatorcontrib><creatorcontrib>Sloth, Carsten</creatorcontrib><creatorcontrib>Torp‐Pedersen, Christian</creatorcontrib><creatorcontrib>Nielsen, Steen Levin</creatorcontrib><creatorcontrib>Hildebrandt, Per</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seibæk, Marie</au><au>Vestergaard, Henrik</au><au>Burchardt, Hans</au><au>Sloth, Carsten</au><au>Torp‐Pedersen, Christian</au><au>Nielsen, Steen Levin</au><au>Hildebrandt, Per</au><au>Pedersen, Oluf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance and maximal oxygen uptake</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2003-11</date><risdate>2003</risdate><volume>26</volume><issue>11</issue><spage>515</spage><epage>520</epage><pages>515-520</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><coden>CLCADC</coden><abstract>Background: Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown.
Hypothesis: This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the presence of either diabetes or ischemic heart disease.
Methods: The study population comprised 33 patients with and without diabetes and ischemic heart disease. Insulin resistance was measured by a hyperinsulinemic euglycemic clamp; maximal oxygen uptake was measured during a bicycle exercise test.
Results: There was a strong correlation between maximal oxygen uptake and insulin‐stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.
Conclusion: Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>14640466</pmid><doi>10.1002/clc.4960261107</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cardiology (Mahwah, N.J.), 2003-11, Vol.26 (11), p.515-520 |
| issn | 0160-9289 1932-8737 |
| language | eng |
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| source | Open Access: PubMed Central |
| subjects | Biological and medical sciences Cardiology. Vascular system Clinical Investigation Clinical Investigations Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - metabolism Diabetic Angiopathies - physiopathology Exercise - physiology Female Humans insulin resistance Insulin Resistance - physiology Linear Models Male maximal oxygen uptake Medical sciences Middle Aged Muscle, Skeletal - metabolism Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Oxygen - metabolism Physical Fitness Prospective Studies |
| title | Insulin resistance and maximal oxygen uptake |
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