fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder

Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI ada...

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Bibliographic Details
Published in:Human brain mapping 2019-04, Vol.40 (5), p.1608-1617
Main Authors: Lee, Junghee, Reavis, Eric A., Engel, Stephen A., Altshuler, Lori L., Cohen, Mark S., Glahn, David C., Nuechterlein, Keith H., Wynn, Jonathan K., Green, Michael F.
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Psychological
Adolescent
Adult
Aged
Bipolar disorder
Bipolar Disorder - diagnostic imaging
Bipolar Disorder - physiopathology
Bipolar Disorder - psychology
Brain
Brain Mapping
Cortex (cingulate)
Discrimination, Psychological
Empirical analysis
Female
fMRI adaptation
Functional magnetic resonance imaging
Gyrus Cinguli - diagnostic imaging
Gyrus Cinguli - physiopathology
Humans
Image processing
In vivo methods and tests
Magnetic Resonance Imaging
Male
Mental disorders
Middle Aged
neural tuning
Neuroimaging
object processing
Occipital Lobe - diagnostic imaging
Occipital Lobe - physiopathology
Patients
Pattern recognition
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - physiopathology
Schizophrenic Psychology
Selectivity
Visual cortex
Visual Cortex - diagnostic imaging
Visual Cortex - physiopathology
Visual discrimination
Visual Perception
Young Adult
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Summary:Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI adaptation for object perception. About 52 SZ patients, 55 BD patients, and 53 community controls completed an object discrimination task with three conditions: the same object presented twice, two exemplars from the same category, and two exemplars from different categories. We also administered two functional localizer tasks. A region of interest analysis was employed to evaluate a priori hypotheses about the lateral occipital complex (LOC) and early visual cortex (EVC). An exploratory whole brain analysis was also conducted. In the LOC and EVC, controls showed the expected reduced fMRI responses to repeated presentation of the same objects compared with different objects (i.e., fMRI adaptation for objects, p 
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.24472