Evaluation of endothelial function in hypertensive elderly patients by high‐resolution ultrasonography

Background:Multiple investigations, both in experimental models and in middle‐aged patients with essential hypertension, demonstrate impaired endothelium‐dependent vasodilatation. Hypothesis:We attempted to determine whether hypertension still exerts additional negative effect on endothelial functio...

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Bibliographic Details
Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 1999-11, Vol.22 (11), p.705-710
Main Authors: Wang, Xin‐Fang, Deng, You‐Bin, Zhang, Qing‐Ping, Li, Chun‐Lei, Zhang, You‐Gen, Le, Gui‐Rong
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
aging
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity
Brachial Artery - physiopathology
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
endothelial function
Endothelium, Vascular - diagnostic imaging
Endothelium, Vascular - physiopathology
Evaluation Studies as Topic
Female
Humans
hypertension
Hypertension - diagnostic imaging
Hypertension - physiopathology
Male
Matched-Pair Analysis
Medical sciences
Middle Aged
Regional Blood Flow
Regression Analysis
Tropical medicine
Ultrasonography
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Summary:Background:Multiple investigations, both in experimental models and in middle‐aged patients with essential hypertension, demonstrate impaired endothelium‐dependent vasodilatation. Hypothesis:We attempted to determine whether hypertension still exerts additional negative effect on endothelial function of large arteries in hypertensive elderly patients who may already be affected by endothelial dysfunction due to aging. Methods:We compared 13 elderly patients with hypertension [69 ± 9 years, (mean ± standard deviation)] with 13 matched healthy elderly subjects (72 ± 6 years) as controls. Using high‐resolution vascular ultrasound, we measured brachial artery responses to reactive hyperemia (with increased flow causing endothelium‐dependent dilatation) and sublingual nitroglycerin (causing endothelium‐independent dilatation). Results:Flow‐mediated dilatation correlated inversely with age (r = –0.60, p = 0.03) in the controls. Flow‐mediated dilatation was significantly impaired in hypertensive elderly patients (6.7 ± 3.3 vs. 13.3 ± 1.8% in controls, p
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.4960221105