The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Background. The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents. We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in th...

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Bibliographic Details
Published in:BioMed research international 2019, Vol.2019 (2019), p.1-9
Main Authors: Zou, Tangbin, Wu, Hongfu, Wang, Tao, Qin, Jiheng, Xiu, Liangchang, Liu, Jie, Luo, Fei, Wang, Yuhui, Zhu, Shanshan, Yu, Na
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Alcohol use
Alfacalcidol
Biomedical research
Body mass
Calcifediol
Calciferol
Child
Children
Confidence intervals
Fatty liver
Geographical locations
Heterogeneity
Humans
Insulin resistance
Levels
Liver diseases
Meta-analysis
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - pathology
Nutrition
Obesity
Review
Sensitivity analysis
Subgroups
Teenagers
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - pathology
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Summary:Background. The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents. We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in this age group. Methods. Relevant studies conducted before May 20, 2018, were identified from the following electronic databases: PubMed, the Cochrane Library, Embase, and the Chinese CNKI databases. The quality of the included studies was evaluated using the Newcastle Ottawa Scale, and associations between vitamin D levels and NAFLD were estimated using standardised mean differences (SMD) and 95% confidence interval (CI). Subgroup and sensitivity analysis were used to identify sources of heterogeneity, and publication bias was evaluated using funnel plots. Results. Eight articles were included in this meta-analysis. A significant difference was observed between low 25(OH)D levels and NAFLD in children and adolescents (SMD = -0.59, 95%CI = -0.98, -0.20, P < 0.01). Subgroup analysis revealed no differences in the study type, geographic location, BMI, and age subgroups. Conclusions. Low vitamin D levels were associated with NAFLD in children and adolescents.
ISSN:2314-6133
2314-6141
DOI:10.1155/2019/7643542