The CREB/CREM Transcription Factors Negatively Regulate Early Synaptogenesis and Spontaneous Network Activity

The family of CREB (cAMP response element-binding protein) transcription factors are involved in a variety of biological processes including the development and plasticity of the nervous system. In the maturing and adult brain, CREB genes are required for activity-dependent processes, including syna...

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Bibliographic Details
Published in:The Journal of neuroscience 2009-01, Vol.29 (2), p.328-333
Main Authors: Aguado, Fernando, Diaz-Ruiz, Carmen, Parlato, Rosanna, Martinez, Albert, Carmona, Maria A, Bleckmann, Susanne, Urena, Jesus M, Burgaya, Ferran, del Rio, Jose A, Schutz, Gunther, Soriano, Eduardo
Format: Article
Language:English
Subjects:
Age Factors
Animals
Brain - cytology
Brain - embryology
Brain - metabolism
Brief Communications
Calcium - metabolism
Cyclic AMP Response Element Modulator - deficiency
Cyclic AMP Response Element Modulator - physiology
Cyclic AMP Response Element-Binding Protein - deficiency
Cyclic AMP Response Element-Binding Protein - physiology
Embryo, Mammalian
In Vitro Techniques
Mice
Mice, Knockout
Neural Pathways - physiology
Neural Pathways - ultrastructure
Neurons - physiology
Neurons - ultrastructure
Synapses - genetics
Synapses - ultrastructure
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Summary:The family of CREB (cAMP response element-binding protein) transcription factors are involved in a variety of biological processes including the development and plasticity of the nervous system. In the maturing and adult brain, CREB genes are required for activity-dependent processes, including synaptogenesis, refinement of connections and long-term potentiation. Here, we use CREB1(Nescre)CREM(-/-) (cAMP-responsive element modulator) mutants to investigate the role of these genes in stimulus-independent patterns of neural activity at early stages. We show that lack of CREB/CREM genes specifically in neural tissue leads to increased synaptogenesis and to a dramatic increase in the levels of spontaneous network activity at embryonic stages. Thus, the functions of CREB/CREM genes in neural activity differ in distinct periods of neural development.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.5252-08.2009