Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults

Cigarette smoking is often associated with dementia. This association is thought to be mediated by hypoperfusion; however, how smoking behavior relates to cerebral blood flow (CBF) remains unclear. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort (mean age = 50; n...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2019-07, Vol.39 (7), p.1247-1257
Main Authors: Elbejjani, Martine, Auer, Reto, Dolui, Sudipto, Jacobs, David R, Haight, Thaddeus, Goff, David C, Detre, John A, Davatzikos, Christos, Bryan, R Nick, Launer, Lenore J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Behavior
Behavior, Addictive
Cerebrovascular Circulation - physiology
Cigarette Smoking - adverse effects
Cigarette Smoking - physiopathology
Cognition - physiology
Cohort Studies
Compulsive Behavior
Female
Follow-Up Studies
Humans
Male
Original
Regional Blood Flow - physiology
Risk Factors
Smoking Cessation
Young Adult
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Summary:Cigarette smoking is often associated with dementia. This association is thought to be mediated by hypoperfusion; however, how smoking behavior relates to cerebral blood flow (CBF) remains unclear. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort (mean age = 50; n = 522), we examined the association between smoking behavior (status, cumulative pack-years, age at smoking initiation, and years since cessation) and CBF (arterial spin labeling) in brain lobes and regions linked to dementia. We used adjusted linear regression models and tested whether associations differed between current and former-smokers. Compared to never-smokers, former-smokers had lower CBF in the parietal and occipital lobes, cuneus, precuneus, putamen, and insula; in contrast, current-smokers did not have lower CBF. The relationship between pack-years and CBF was different between current and former-smokers (p for interaction 
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X18754973