System-level matching of structural and functional connectomes in the human brain

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2019-10, Vol.199, p.93-104
• Main Authors: Osmanlıoğlu, Yusuf, Tunç, Birkan, Parker, Drew, Elliott, Mark A., Baum, Graham L., Ciric, Rastko, Satterthwaite, Theodore D., Gur, Raquel E., Gur, Ruben C., Verma, Ragini
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Age Factors; Attention; Brain - anatomy & histology; Brain - diagnostic imaging; Brain - physiology; Brain mapping; Brain research; Child; Communication; Connectome - methods; Connectomics; Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging - methods; Female; Functional anatomy; Functional magnetic resonance imaging; Gender differences; Humans; Information processing; Large-scale systems; Magnetic Resonance Imaging - methods; Male; MRI; Nerve Net - anatomy & histology; Nerve Net - diagnostic imaging; Nerve Net - physiology; Network analysis; Neural networks; Sensorimotor integration; Sex Factors; Sexes; Structure-function matching; Structure-function relationships; Studies; Traumatic brain injury; Visual perception; Young Adult
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2019.05.064

The brain can be considered as an information processing network, where complex behavior manifests as a result of communication between large-scale functional systems such as visual and default mode networks. As the communication between brain regions occurs through underlying anatomical pathways, it is important to define a “traffic pattern” that properly describes how the regions exchange information. Empirically, the choice of the traffic pattern can be made based on how well the functional connectivity between regions matches the structural pathways equipped with that traffic pattern. In this paper, we present a multimodal connectomics paradigm utilizing graph matching to measure similarity between structural and functional connectomes (derived from dMRI and fMRI data) at node, system, and connectome level. Through an investigation of the brain's structure-function relationship over a large cohort of 641 healthy developmental participants aged 8–22 years, we demonstrate that communicability as the traffic pattern describes the functional connectivity of the brain best, with large-scale systems having significant agreement between their structural and functional connectivity patterns. Notably, matching between structural and functional connectivity for the functionally specialized modular systems such as visual and motor networks are higher as compared to other more integrated systems. Additionally, we show that the negative functional connectivity between the default mode network (DMN) and motor, frontoparietal, attention, and visual networks is significantly associated with its underlying structural connectivity, highlighting the counterbalance between functional activation patterns of DMN and other systems. Finally, we investigated sex difference and developmental changes in brain and observed that similarity between structure and function changes with development.