The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress

Attenuating post-injury neuroendocrine stress abrogates persistent injury-associated anemia. Our objective was to examine the mechanisms by which propranolol and clonidine modulate this process. We hypothesized that propranolol and clonidine would decrease bone marrow expression of high-mobility gro...

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Bibliographic Details
Published in:The American journal of surgery 2019-11, Vol.218 (5), p.858-863
Main Authors: Loftus, Tyler J., Miller, Elizabeth S., Millar, Jessica K., Kannan, Kolenkode B., Alamo, Ines G., Efron, Philip A., Mohr, Alicia M.
Format: Article
Language:English
Subjects:
Anemia
Anemia - etiology
Anemia - prevention & control
Animals
B-cell lymphoma
Bcl-x protein
Biomarkers - metabolism
Blood pressure
Bone marrow
Bone Marrow - drug effects
Bone Marrow - metabolism
Chronic Disease
Clonidine
Clonidine - pharmacology
Clonidine - therapeutic use
Contusions
Contusions - drug therapy
Contusions - physiopathology
Cytokines
Cytokines - metabolism
Drug Therapy, Combination
Erythropoiesis
Erythropoiesis - drug effects
Hematinics - pharmacology
Hematinics - therapeutic use
Hemoglobin
Hemorrhage
Hemorrhagic shock
HMGB1 protein
Injuries
Injury
Laboratories
Lung Injury - drug therapy
Lung Injury - physiopathology
Lymphocytes B
Lymphoma
Male
Phlebotomy
Polymerase chain reaction
Propranolol
Propranolol - pharmacology
Propranolol - therapeutic use
Random Allocation
Rats
Rats, Sprague-Dawley
Restraint, Physical
Shock, Hemorrhagic - drug therapy
Shock, Hemorrhagic - physiopathology
Stem cell factor
Stem cells
Stress
Stress response
Stress, Physiological - physiology
Studies
Trauma
Treatment Outcome
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Summary:Attenuating post-injury neuroendocrine stress abrogates persistent injury-associated anemia. Our objective was to examine the mechanisms by which propranolol and clonidine modulate this process. We hypothesized that propranolol and clonidine would decrease bone marrow expression of high-mobility group box-1 (HMGB1) and increase expression of stem cell factor (SCF) and B-cell lymphoma-extra large (Bcl-xL). Male Sprague-Dawley rats were allocated to naïve control, lung contusion followed by hemorrhagic shock (LCHS), or LCHS plus daily chronic restraint stress (LCHS/CS) ±propranolol, ±clonidine. Day seven bone marrow expression of HMGB1, SCF, and Bcl-xL was assessed by polymerase chain reaction. Following LCHS, HMGB1 was decreased by propranolol (49% decrease, p = 0.012) and clonidine (54% decrease, p 
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2019.02.023