Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse

• Published in: Genomics (San Diego, Calif.) Calif.), 1995-02, Vol.25 (3), p.727-729
• Main Authors: Huppi, K., Siwarski, D., Pisegna, J.R., Wank, S.
• Format: Article
• Language: English
• Subjects: Animals; Base Sequence; Biological and medical sciences; brain; Brain Chemistry; cholecystokinin receptors; chromosome 4; chromosome 5; Chromosome Mapping; Chromosomes, Human, Pair 4; Classical genetics, quantitative genetics, hybrids; Cricetinae; DNA Primers; Fundamental and applied biological sciences. Psychology; gene mapping; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; Hybrid Cells; man; mental disorders; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Polymerase Chain Reaction; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin - genetics; Receptors, Dopamine - genetics; stomach; Stomach - chemistry
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/0888-7543(95)80018-H

Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCK AR and CCK BR. In an effort to determine whether the CCK A and CCK B receptors may be associated with certain CNS or gastrointestinal diseases, we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes. The gene encoding the CCK A receptor maps to a syntenic region of human chromosome 4 and mouse chromosome 5. The CCK B receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Localization of the CCK receptors with two dopamine receptors, DRD5 (4p15.1–p15.3) and DRD4 (11p15), provides the interesting possibility of coinvolvement in neuropsychiatric or CNS illnesses.