Extraclassical Receptive Field Properties of Parvocellular, Magnocellular, and Koniocellular Cells in the Primate Lateral Geniculate Nucleus

• Published in: The Journal of neuroscience 2002-01, Vol.22 (1), p.338-349
• Main Authors: Solomon, Samuel G, White, Andrew J. R, Martin, Paul R
• Format: Article
• Language: English
• Subjects: Animals; Callithrix; Contrast Sensitivity - physiology; Evoked Potentials, Visual - physiology; Geniculate Bodies - physiology; Male; Microelectrodes; Models, Neurological; Neural Inhibition - physiology; Neurons - classification; Neurons - physiology; Photic Stimulation - methods; Visual Pathways - physiology
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/jneurosci.22-01-00338.2002

Descriptions of receptive fields at subcortical levels of the visual system have mostly considered only the classical receptive field (CRF). A suppressive extraclassical receptive field (ECRF) has been demonstrated in relay cells within the primate lateral geniculate nucleus (LGN), but the quantitative properties and specific influence of the ECRF on the distinct magnocellular (MC), koniocellular (KC), and parvocellular (PC) pathways are not known. Here we quantified the effect of ECRF stimulation on visually responsive cells in the LGN of a diurnal New World primate, the marmoset. We show that for all cells, visually evoked responses are reduced by stimulation of the ECRF. The magnitude of the suppression is greatest for MC cells and smallest for PC cells. The effect of ECRF stimulation on KC cells is variable but always suppressive. We refer to these effects as extraclassical inhibition (ECI). The contrast-response relationship of the ECI parallels that of CRF-induced excitation for each cell class: for MC cells, ECI contrast threshold is close to 10% and the ECI saturates at 50% contrast, but the contrast dependence of ECI on PC cells is more linear. The ECI also contributes to contrast-dependent changes in spatial summation: on average for all LGN cells the radius of the excitatory spatial summation field (measured from aperture-tuning curves) at low contrast is 1.31 times that at high contrast. No consistent effects of orientation on ECI were seen. The data suggest that the suppressive component of the ECRF seen in cortical neurons could primarily be inherited from subcortical input streams.