Ferritin levels throughout childhood and metabolic syndrome in adolescent stage

Increased ferritin levels have been widely associated with cardiovascular risk in adults. Whether ferritin levels and their changes during childhood are related to metabolic syndrome (MetS) at adolescence is unknown. We aimed to evaluate these associations using levels of ferritin at 5, 10 and 16 ye...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2019-03, Vol.29 (3), p.268-278
Main Authors: Suárez-Ortegón, M.F., Blanco, E., McLachlan, S., Fernandez-Real, J.M., Burrows, R., Wild, S.H., Lozoff, B., Gahagan, S.
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Biomarkers - blood
Child
Child, Preschool
Children
Chile - epidemiology
Female
Ferritin
Ferritins - blood
Humans
Iron
Longitudinal Studies
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Prognosis
Risk Assessment
Risk Factors
Sex Factors
Up-Regulation
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Summary:Increased ferritin levels have been widely associated with cardiovascular risk in adults. Whether ferritin levels and their changes during childhood are related to metabolic syndrome (MetS) at adolescence is unknown. We aimed to evaluate these associations using levels of ferritin at 5, 10 and 16 years and their linear increases and patterns of sustained increased levels across childhood. There were four samples evaluated according to non-missing values for study variables at each stage (5 years: 562; 10 years: 381; and 16 years: 567 children; non-missing values at any stage: 379). MetS risk was evaluated as a continuous Z score. Patterns of sustained increased ferritin (highest tertile) and slope of the change of ferritin per year across the follow-up were calculated. Ferritin levels in the highest versus lowest tertile at five and 16 years were significantly positively associated with MetS risk Z score at adolescence in boys and these associations were unaffected by adjustment for covariates. Having high, compared to low/moderate ferritin level at 2 or more time periods between 5 and 16 years was related to higher Mets Z-score in boys only [e.g. 5–10 years adjusted-beta (95 %CI):0.26 (0.05–0.48),P 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2018.11.008