Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy

Second primary malignancy (SPM) may occur after index head and neck cancer (HNC) treatment. This study evaluated the prevalence and outcome of SPM in patients with HNC treated with definitive radiotherapy. Eligible patients include those with index mucosal HNC treated with definitive radiotherapy be...

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Bibliographic Details
Published in:NPJ precision oncology 2019-09, Vol.3 (1), p.22-22, Article 22
Main Authors: Ng, Sweet Ping, Pollard, Courtney, Kamal, Mona, Ayoub, Zeina, Garden, Adam S., Bahig, Houda, Gunn, G. Brandon, Frank, Steven J., Skinner, Heath D., Phan, Jack, Berends, Joel, Morrison, William H., Johnson, Jason M., Ferrarotto, Renata, Sturgis, Erich M., Mohamed, Abdallah S. R., Lai, Stephen Y., Fuller, Clifton D., Rosenthal, David I.
Format: Article
Language:English
Subjects:
692/4028/67/1536
692/4028/67/2324
Cancer Research
Gene Therapy
Head & neck cancer
Human Genetics
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Precision medicine
Radiation therapy
Targeted cancer therapy
Throat cancer
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Summary:Second primary malignancy (SPM) may occur after index head and neck cancer (HNC) treatment. This study evaluated the prevalence and outcome of SPM in patients with HNC treated with definitive radiotherapy. Eligible patients include those with index mucosal HNC treated with definitive radiotherapy between 2000 and 2010. SPM was defined as an invasive cancer at a noncontiguous site diagnosed at least 6 months after completion of radiotherapy. Clinical data were collected, and the Kaplan–Meier method was used to estimate overall survival. In total, 1512 patients were studied. The majority of patients had index oropharyngeal cancer (86%). In all, 130 (9%) patients developed a SPM. The risk of SPM increased exponentially with time with 5-, 10-, and 15-year rates of 4, 10, and 25%. Half of SPMs were within the head and neck or thoracic regions. SPM rates were significantly higher ( p  
ISSN:2397-768X
2397-768X
DOI:10.1038/s41698-019-0097-y