p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill

Loss of tumor suppression by the p53 protein involves altered or abrogated transcriptional activity resulting in a failure to mediate wild‐type cellular responses including cell cycle arrest, senescence, and apoptosis. Timofeev et al (2019) make the fascinating finding that a novel p53 cooperativity...

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Bibliographic Details
Published in:The EMBO journal 2019-10, Vol.38 (20), p.e103322-n/a
Main Author: Manfredi, James J
Format: Article
Language:English
Subjects:
Apoptosis
Carcinogenesis
Cell cycle
Cell Cycle Checkpoints
Chemotherapy
EMBO03
EMBO07
EMBO24
Humans
Mutation
News & Views
p53 Protein
Senescence
Transcription
Tumor suppression
Tumor Suppressor Protein p53 - genetics
Tumors
Views
Citations: Items that this one cites
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Summary:Loss of tumor suppression by the p53 protein involves altered or abrogated transcriptional activity resulting in a failure to mediate wild‐type cellular responses including cell cycle arrest, senescence, and apoptosis. Timofeev et al (2019) make the fascinating finding that a novel p53 cooperativity mutation devoid of DNA binding results in no tumor suppression but surprising retention of an apoptotic response to chemotherapy and other treatments. This shows a need for rethinking how mutant p53‐driven tumors are treated in the clinic. Graphical Abstract A new genetic mouse model disentangles p53's roles in cancer progression versus apoptosis.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2019103322