Associations of serum sex hormone binding globulin with bone mineral densities and higher 10-year probability of fractures in postmenopausal women with type 2 diabetes mellitus

Postmenopause and type 2 diabetes mellitus (T2DM) are associated with higher fracture risk. Sex hormones are important in maintaining woman skeleton health. The relationships of sex hormone(s) with bone mineral density (BMD) and fracture risk are still unclear in diabetic-postmenopausal women. This...

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Published in:Annals of translational medicine 2019-09, Vol.7 (18), p.457-457
Main Authors: Jing, Yixuan, Wang, Xiaofeng, Yu, Jingjia, Wang, Xiaojing, Zhou, Yanman, Tao, Bei, Sun, Lihao, Liu, Jianmin, Zhao, Hongyan
Format: Article
Language:English
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Summary:Postmenopause and type 2 diabetes mellitus (T2DM) are associated with higher fracture risk. Sex hormones are important in maintaining woman skeleton health. The relationships of sex hormone(s) with bone mineral density (BMD) and fracture risk are still unclear in diabetic-postmenopausal women. This study aimed to investigate the relationships of sex hormones with BMDs and fracture risk in postmenopausal women with T2DM. Two hundred and fourteen postmenopausal women with T2DM were included. BMDs at lumbar spine (L2-4), femoral neck (FN) and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). The 10-year probability of fractures was accessed by modified fracture risk algorithm (FRAX) tool. Serum concentrations of sex hormones were measured. Sex hormone binding globulin (SHBG) was a determinant of BMDs at L2-4 (β=-0.199, P
ISSN:2305-5839
2305-5839
DOI:10.21037/atm.2019.08.46