Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

• Published in: Journal of clinical laboratory analysis 2014-03, Vol.28 (2), p.157-162
• Main Authors: Yamashita, Eliana K., Teixeira, Bianca M., Yoshihara, Renata N., Kuniyoshi, Renata K., Alves, Beatriz C.A., Gehrke, Flávia S., Vilas-Bôas, Viviane A., Correia, João A., Azzalis, Ligia A., Junqueira, Virginia B.C., Pereira, Edimar Cristiano, Fonseca, Fernando L.A.
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Blood Platelets - drug effects; Blood Platelets - metabolism; Breast cancer; breast neoplasms; Breast Neoplasms - diagnosis; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Chemotherapy; chemotherapy and thromboembolism; Female; folic acid; Folic Acid - blood; Health risk assessment; Homocysteine; Homocysteine - blood; Homocysteine - metabolism; Humans; Metabolism; Middle Aged; vitamin B 12; Vitamin B 12 - blood
• ISSN: 0887-8013; 1098-2825; 1098-2825
• DOI: 10.1002/jcla.21660

Background Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data. Methods Thirty‐five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method. Platelet count was done using an automated analyzer. Statistical analysis was performed using the software SPSS. Results During chemotherapy, homocysteine (P = 0.032) and vitamin B12 (P < 0.001) concentrations increased, while folate and platelets decreased (P < 0.001). Among the clinical data, the menopausal status showed significant positive correlation (P = 0.022) with homocysteine concentration increase. Conclusions Evaluation of homocysteine concentrations during chemotherapy is extremely important because their levels increase during chemotherapy treatment, thus increasing the risk of thromboembolism development.