Visfatin Levels in Nonalcoholic Fatty Liver Disease

Purpose Recently, role of adipokin in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has been suggested. Among adipokins, role of leptin and adiponectin is rather well known; however, there are only a few data concerning visfatin. Material and Methods NAFLD is confirmed in 30 patients...

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Published in:Journal of clinical laboratory analysis 2012-02, Vol.26 (2), p.115-119
Main Authors: Akbal, Erdem, Koçak, Erdem, Taş, Adnan, Yüksel, Enver, Köklü, Seyfettin
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Demography
Fatty Liver - blood
Female
Humans
Male
Nicotinamide Phosphoribosyltransferase - blood
Non-alcoholic Fatty Liver Disease
nonalcoholic fatty liver disease
Original
visfatin
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Summary:Purpose Recently, role of adipokin in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has been suggested. Among adipokins, role of leptin and adiponectin is rather well known; however, there are only a few data concerning visfatin. Material and Methods NAFLD is confirmed in 30 patients by ultrasonography. As a control group, patients without fatty liver or other liver diseases were included. Viral hepatitis, metabolic liver diseases, and autoimmune hepatitis and consumption of alcohol were excluded in all patients. Fasting serum level of visfatin was determined by ELISA method. Results Serum visfatin concentration in the NAFLD group (14.7 ± 8.1 ng/ml) was significantly higher than in controls (9.4 ± 1.6 ng/ml) (P < 0.001). There were no correlations between visfatin and anthropometric parameters, transaminases, lipids, and homeostasis model assessment‐estimated insulin resistance (HOMA‐IR). Conclusion Serum visfatin concentration increases in patients with NAFLD.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.21491