Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial

IntroductionMetabolic syndrome (MetS) has been recognized as one of the most important clinical challenges and global health issues of today. Growing evidence suggests that mechanisms of energy metabolism may also play a key role in mediating aspects of cognitive function. Brain-derived neurotrophic...

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Published in:Curēus (Palo Alto, CA) CA), 2019-09, Vol.11 (9), p.e5604-e5604
Main Authors: Gyorkos, Amy, Baker, Mark H, Miutz, Lauren N, Lown, Deborah A, Jones, Michael A, Houghton-Rahrig, Lori D
Format: Article
Language:English
Subjects:
Brain-derived neurotrophic factor
Carbohydrates
Cognition & reasoning
Cognitive ability
Diet
Disease prevention
Endocrinology/Diabetes/Metabolism
Epidemiology/Public Health
Exercise
Health care
Heart rate
Homeostasis
Insulin resistance
Interval training
Lifestyles
Metabolic syndrome
Muscle contraction
Musculoskeletal system
Obesity
Paleolithic
Physical fitness
Preventive Medicine
Researchers
Weight control
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Summary:IntroductionMetabolic syndrome (MetS) has been recognized as one of the most important clinical challenges and global health issues of today. Growing evidence suggests that mechanisms of energy metabolism may also play a key role in mediating aspects of cognitive function. Brain-derived neurotrophic factor (BDNF) is one such factor well known for its critical role in neuronal plasticity, including memory and learning, and more recently metabolic processes. BDNF levels have been shown separately to be dependent on diet and exercise programming.PurposeThe purpose of this study was to investigate the effect of diet and exercise on BDNF levels and cognitive functioning with any metabolic association in individuals characterized with MetS.MethodsTwelve subjects with MetS followed a randomized crossover design with two four-week interventions, including a carbohydrate (CHO)-restricted Paleolithic-based diet (CRPD;
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.5604