C-reactive protein and stroke risk in blacks and whites: The REasons for Geographic And Racial Differences in Stroke cohort

C-reactive protein (CRP) is an inflammatory biomarker used in vascular risk prediction, though with less data in people of color. Blacks have higher stroke incidence and also higher CRP than whites. We studied the association of CRP with ischemic stroke risk in blacks and whites. REGARDS, an observa...

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Bibliographic Details
Published in:The American heart journal 2019-11, Vol.217, p.94-100
Main Authors: Evans, Christina R., Long, D. Leann, Howard, George, McClure, Leslie A., Zakai, Neil A., Jenny, Nancy S., Kissela, Brett M., Safford, Monika M., Howard, Virginia J., Cushman, Mary
Format: Article
Language:English
Subjects:
African Americans
Aged
Awards & honors
Biomarkers
Biomarkers - blood
Black People - statistics & numerical data
Blood pressure
C-reactive protein
C-Reactive Protein - analysis
Cardiac arrhythmia
Cardiovascular disease
Cardiovascular diseases
Continuity (mathematics)
Coronary artery disease
Diabetes
Female
Health hazards
Health risks
Heart diseases
Hematology
Humans
Hypertension
Incidence
Inflammation
Ischemia
Longitudinal Studies
Male
Mathematical analysis
Medical records
Middle Aged
Mortality
Proteins
Race
Racial differences
Regression analysis
Risk analysis
Risk Assessment
Risk Factors
Stroke
Stroke - blood
Stroke - epidemiology
Stroke - ethnology
White people
White People - statistics & numerical data
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Summary:C-reactive protein (CRP) is an inflammatory biomarker used in vascular risk prediction, though with less data in people of color. Blacks have higher stroke incidence and also higher CRP than whites. We studied the association of CRP with ischemic stroke risk in blacks and whites. REGARDS, an observational cohort study, recruited and followed 30,239 black and white Americans 45 years and older for ischemic stroke. We calculated hazard ratios and 95% CIs of ischemic stroke by CRP category (10 mg/L, whereas in blacks, an association was only seen for CRP >10 mg/L. Considered as a continuous variable, the risk factor–adjusted hazard ratios per SD higher lnCRP were 1.18 (95% CI 1.09-1.28) overall, 1.14 (95% CI 1.00-1.29) in blacks, and 1.22 (95% CI 1.10-1.35) in whites. Spline regression analysis visually confirmed the race difference in the association. CRP may not be equally useful in stroke risk assessment in blacks and whites. Confirmation, similar study for coronary heart disease, and identification of reasons for these racial differences require further study.
ISSN:0002-8703
1097-6744
1097-6744
DOI:10.1016/j.ahj.2019.08.003