Astragalus polysaccharide strengthens the inflammatory and immune responses of Brucella suis S2‑infected mice and macrophages

Brucella infection is one of the most serious zoonoses worldwide, affecting humans and domestic and wild animals. Astragalus polysaccharide (APS) is extracted from astragalus, which exhibits bioactive properties, including immunomodulation and anti-tumour and antiviral activity. The present study re...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2019-12, Vol.18 (6), p.4295-4302
Main Authors: Shi, Qiwen, Zhao, Lan, Zhang, Leifang
Format: Article
Language:English
Subjects:
Abortion
Antigens
Antiviral agents
Apoptosis
Bacteria
Beef cattle
Biological response modifiers
Brucellosis
Cytokines
Health aspects
Immune response
Infection
Infections
Interferon
Interleukins
Laboratory animals
Lymphocytes
Macrophages
Medical research
Necrosis
Nitric oxide
Nitrogen oxides
Pathogens
Polysaccharides
Scientific equipment industry
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumors
Vaccines
Wildlife
Zoonoses
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Summary:Brucella infection is one of the most serious zoonoses worldwide, affecting humans and domestic and wild animals. Astragalus polysaccharide (APS) is extracted from astragalus, which exhibits bioactive properties, including immunomodulation and anti-tumour and antiviral activity. The present study revealed that APS treatment promoted macrophage activation, the production of pro-inflammatory cytokines, including tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin-12 and interferon-[gamma], and Brucella clearance in murine macrophages and spleens. APS treatment was also demonstrated to protect the integrity of macrophages during infection with live attenuated Brucella suis strain 2 (B. suis S2). The results from in vitro experiments were consistent with the findings from the in vivo study, showing the elevated secretion of TNF-[alpha] and nitric oxide in APS-treated murine peritoneal macrophages following B. suis S2 infection. The current study demonstrated the potential of APS in the control and treatment of Brucella infection, and the enhancement of host inflammatory and immune responses. Key words: Brucella suis strain 2, brucellosis, astragalus polysaccharide, macrophages, cytokines
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2019.8084