Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing-remitting multiple sclerosis

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional integrity of cerebellar networks and connec...

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Published in:Human brain mapping 2015-04, Vol.36 (4), p.1609-1619
Main Authors: Romascano, David, Meskaldji, Djalel-Eddine, Bonnier, Guillaume, Simioni, Samanta, Rotzinger, David, Lin, Ying-Chia, Menegaz, Gloria, Roche, Alexis, Schluep, Myriam, Pasquier, Renaud Du, Richiardi, Jonas, Van De Ville, Dimitri, Daducci, Alessandro, Sumpf, Tilman, Fraham, Jens, Thiran, Jean-Philippe, Krueger, Gunnar, Granziera, Cristina
Format: Article
Language:English
Subjects:
Adult
Cerebellum - pathology
Cerebellum - physiopathology
Connectome - methods
connectometry
diffusion MRI
Female
Humans
Magnetic Resonance Imaging - methods
Male
multicontrast
multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - pathology
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Neural Pathways - pathology
Neural Pathways - physiopathology
Rest
resting-state MRI
Review
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Summary:Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional integrity of cerebellar networks and connectivity in early MS. Methods: We used diffusion spectrum and resting‐state functional MRI (rs‐fMRI) to establish the structural and functional cerebellar connectomes in 28 early relapsing‐remitting MS patients and 16 healthy controls (HC). We performed multicontrast “connectometry” by quantifying multiple MRI parameters along the structural tracts (generalized fractional anisotropy‐GFA, T1/T2 relaxation times and magnetization transfer ratio) and functional connectivity measures. Subsequently, we assessed multivariate differences in local connections and network properties between MS and HC subjects; finally, we correlated detected alterations with lesion load, disease duration, and clinical scores. Results: In MS patients, a subset of structural connections showed quantitative MRI changes suggesting loss of axonal microstructure and integrity (increased T1 and decreased GFA, P 
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.22698