Significant upregulation of small heat shock protein αA-crystallin in retinal detachment

•αA-crystallin is a small heat shock protein involved in neuroprotection during stress.•αA-crystallin is significantly upregulated in murine experimental RD at the transcriptional and translational levels.•αA-crystallin levels are significantly increased in the vitreous samples from pseudophakic pat...

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Bibliographic Details
Published in:Experimental eye research 2019-12, Vol.189, p.107811-107811, Article 107811
Main Authors: Hamadmad, Sumaya, Shah, Mohd Hussain, Kusibati, Rania, Kim, Bongsu, Erickson, Brandon, Heisler-Taylor, Tyler, Bhattacharya, Sanjoy K., Abdel-Rahman, Mohamed H., Cebulla, Colleen M., Van Law, Heather, Davidorf, Frederick H., Ohr, Matthew, Wells, Michael, Yanoga, Fatoumata, Chang, Susie, Terrell, William, Miller, Daniel M., Klisovic, Dino, Allen, John B., Shah, Niraj, Geraymovych, Elena, Tarabishy, Ahmad B., Kondapalli, Srinivas S., Brewington, Beatrice Y., Inman, Andrea, Williams, Demarcus, Mathias, Jay, Wisely, C. Ellis, Pilarski, Robert
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
alpha-Crystallin A Chain - biosynthesis
alpha-Crystallin A Chain - genetics
Animals
Blotting, Western
Female
Gene Expression Regulation
Heat-Shock Proteins, Small - biosynthesis
Heat-Shock Proteins, Small - genetics
Humans
Immunohistochemistry
Male
Mice
Middle Aged
Retina - metabolism
Retina - pathology
Retinal Detachment - genetics
Retinal Detachment - metabolism
Retinal Detachment - pathology
RNA - genetics
Up-Regulation
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Summary:•αA-crystallin is a small heat shock protein involved in neuroprotection during stress.•αA-crystallin is significantly upregulated in murine experimental RD at the transcriptional and translational levels.•αA-crystallin levels are significantly increased in the vitreous samples from pseudophakic patients with RD.•Our data provide a platform for further studies to evaluate the potential therapeutic value of αA-crystallin in RD.
ISSN:0014-4835
1096-0007
DOI:10.1016/j.exer.2019.107811