Survival impact of primary tumor resection in de novo metastatic breast cancer patients (GEICAM/El Alamo Registry)

The debate about surgical resection of primary tumor (PT) in de novo metastatic breast cancer (MBC) patients persists. We explored this approach’s outcomes in patients included in a retrospective registry, named El Álamo , of breast cancer patients diagnosed in Spain (1990–2001). In this analysis we...

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Published in:Scientific reports 2019-12, Vol.9 (1), p.20081-12, Article 20081
Main Authors: Lopez-Tarruella, Sara, Escudero, M. J., Pollan, Marina, Martín, Miguel, Jara, Carlos, Bermejo, Begoña, Guerrero-Zotano, Angel, García-Saenz, José, Santaballa, Ana, Alba, Emilio, Andrés, Raquel, Martínez, Purificación, Calvo, Lourdes, Fernández, Antonio, Batista, Norberto, Llombart-Cussac, Antonio, Antón, Antonio, Lahuerta, Ainhara, de la Haba, Juan, López-Vega, José Manuel, Carrasco, E.
Format: Article
Language:English
Subjects:
692/4028/67/1347
692/4028/67/2324
Aged
Bone surgery
Bone tumors
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Clinical trials
Female
Humanities and Social Sciences
Humans
Metastases
Metastasis
Middle Aged
multidisciplinary
Neoplasm Metastasis
Registries
Retrospective Studies
Science
Science (multidisciplinary)
Spain - epidemiology
Statistical analysis
Surgery
Survival
Tumors
Viscera
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Summary:The debate about surgical resection of primary tumor (PT) in de novo metastatic breast cancer (MBC) patients persists. We explored this approach’s outcomes in patients included in a retrospective registry, named El Álamo , of breast cancer patients diagnosed in Spain (1990–2001). In this analysis we only included de novo MBC patients, 1415 of whom met the study’s criteria. Descriptive, Kaplan-Meier and Cox regression analyses were carried out. Median age was 63.1 years, 49.2% of patients had single-organ metastasis (skin/soft tissue [16.3%], bone [33.8%], or viscera [48.3%]). PT surgery (S) was performed in 44.5% of the cases. S-group patients were younger, had smaller tumors, higher prevalence of bone and oligometastatic disease, and lower prevalence of visceral involvement. With a median follow-up of 23.3 months, overall survival (OS) was 39.6 versus 22.4 months (HR = 0.59, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-55765-9