Insulin Resistance in Type 1 Diabetes Mellitus and Its Association with Patient’s Micro- and Macrovascular Complications, Sex Hormones, and Other Clinical Data

Introduction The main objective of this research was to evaluate the association of insulin resistance (IR) with micro- and macrovascular complications, sex hormones, and other clinical data. Methods Cross-sectional study of patients older than 18 years old with type 1 diabetes mellitus (T1DM) was p...

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Bibliographic Details
Published in:Diabetes therapy 2020-01, Vol.11 (1), p.161-174
Main Authors: Šimonienė, Diana, Platūkiene, Aksana, Prakapienė, Edita, Radzevičienė, Lina, Veličkiene, Džilda
Format: Article
Language:English
Subjects:
Cardiology
Complications and side effects
Diabetes
Diabetic neuropathy
Diagnosis
Endocrinology
Family medical history
Health aspects
Hormones
Hormones, Sex
Hypertension
Insulin resistance
Internal Medicine
Medical records
Medicine
Medicine & Public Health
Metabolism
Original Research
Risk factors
Testosterone
Type 1 diabetes
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Summary:Introduction The main objective of this research was to evaluate the association of insulin resistance (IR) with micro- and macrovascular complications, sex hormones, and other clinical data. Methods Cross-sectional study of patients older than 18 years old with type 1 diabetes mellitus (T1DM) was performed. Participants filled in questionnaires about T1D, disease duration, smoking, glycemic control, chronic diabetes complications, and hypertension status. Data about chronic diabetic complications (neuropathy, retinopathy, and nephropathy) were collected from medical records. History of major cardiovascular events such as angina, myocardial infarction, and stroke were collected from medical records also. Laboratory tests including creatinine, cholesterol levels, testosterone (T), sex hormone-binding globulin (SHBG), estradiol levels, and albumin in 24-h urine sample were performed. IR was calculated using the following formula: estimated glucose disposal rate (eGDR) = 24.31 − [12.22 × waist-to-hip ratio (WHR)] − [3.29 ×  hypertension status (defined as 0 = no, 1 = yes)] − [0.57 × glycated hemoglobin (HbA1c)]. The data was considered statistically significant at p  
ISSN:1869-6953
1869-6961
DOI:10.1007/s13300-019-00729-5